Functional Neuroanatomy of Pain

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Javascript is not enabled in your browser. Enabling JavaScript in your browser will allow you to experience all the features of our site. Learn how to enable JavaScript on your browser. Pain is an unpleasant but very important biological signal for danger.

Nociception is necessary for survival and maintaining the integrity of the organism in a potentially hostile environment.


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Pain is both a sensory experience and a perceptual metaphor for damage and it is activated by noxious stimuli that act on a complex pain sensory apparatus. However, chronic pain having no more a protective role can become a ruining disease itself, termed "neuropathic pain". From the results of human studies there is growing evidence that these different cortical structures contribute to different dimensions of pain experience.

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The SI cortex appears to be mainly involved in sensory-discriminative aspects of pain. The SII cortex seems to have an important role in recognition, learning, and memory of painful events.

The insula has been proposed to be involved in autonomic reactions to noxious stimuli and in affective aspects of pain-related learning and memory. The ACC is closely related to pain unpleasantness and may subserve the integration of general affect, cognition, and response selection. The authors review the evidence on which the proposed relationship between cortical areas, pain-related neural activations, and components of pain perception is based.


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    On the other hand, it can make for a less comprehensive knowledge of the detailed anatomy of discrete levels of the neuraxis, something which is important for more advanced study of the subject. One would also do.

    Kirschberg GJ. Functional Neuroanatomy.

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    Arch Neurol. All Rights Reserved. Twitter Facebook Email. This Issue. Gordon J. Kirschberg, MD. First Page Preview View Large.

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